Our Client's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.
Duties:
The Cardiac Biology group conducts preclinical translational research to evaluate potential therapeutics for cardiac diseases with high unmet medical needs. Our cell biology group models cardiac disease in cell-based systems to identify new areas of cardiovascular research, and to understand the molecular and cellular mechanisms of action for a wide range of therapeutic modalities, including gene therapy, oligonucelotide, small molecule, and peptide approaches.
We are seeking a highly motivated and skilled individual to join our cardiovascular cell biology group. The position offers a unique opportunity to develop therapeutics from the early exploratory stage across a wide range of inherited cardiac disease indications. Cell biology work in the lab will focus on 1-2 projects, often taking on the Cell Biology Functional Lead on Project Teams. The successful candidate will be a proactive self-starter, with clear passion to progress scientific discoveries, and an ability to thrive in a fast-paced colloborative team environment. He/She will communicate scientific findings at Team Meetings, as well as at several forums throughout the company. She/He will partner closely with other senior research associates and scientists with different skillsets to support the discovery and pre-clinical development of a wide-range of therapeutic modalities.
- Investigate, identify, develop, and optimize cellular modeling of cardiac disease.
- Must be able to work in a team environment, with a proven rack record of productive collaborative research experience.
- Participates and presents their data at team and department meetings, often taking the primary functional lead on team projects.
- Proactively troubleshoots technical issues and recommends corrective actions.
- Working knowledge of any of following is beneficial but not necessary: functional cardiomyocyte assays, experience with culturing iPS-derived cardiomyocytes, monitoring cardiac cell function with cardio xCELLigence or by high speed calicum imaging, force traction microscopy, confocal microscopy, high content imaging, live cell imaging, CRIPSR editing, electrophysiology.
Skills:
- Technical experience in cell biology, cell signaling, genetics, gene therapy, biochemistry, molecular biology, physiology, pharmacology, or other related field.
- Working experience with adherent cells, plate-based assays, downstream biochemistry and/or cell imaging.
- Technical experience with successful development of reporter, proliferation, potency, survival, functional or cell signaling assays using lentiviral or other viral / non-viral gene transduction systems in mamalian cells (primary cells, immortalized cell lines, and / or iPSC-derived cell lines).
- Advanced skills in experimental design, data analysis, and data presentation.
- Excellent organizational, documentation, and communication skills; adaptive learning, critical thinking, friendly and approachable, professional, and the ability to work well in a fast-paced team environment.
Education:
Bachelor’s degree with 6-8 years of experience; Master’s degree with at least 4 - 6years of relevant experience