| Duties: |
Position Summary: The Biology Department at our client is looking for a qualified Senior Research Associate with expertise in protein expression, purification, and assay development to understand mechanisms of disease and treatment. The successful candidate will join a multi-disciplinary team and support our structural biology platform in drug discovery effort by protein cloning, expression and purification, and biochemical and cell-based assay development to translate SAR insight into testable hypotheses. This senior research associate will play a major role in performing, improving, and automating protein expression workflows, from cloning to purification. The ideal candidate will be highly motivated, detail-oriented, and can collaborate in a cross-functional team.
Responsibilities:
- This Senior Research Associate will play a major role in performing, improving, and automating protein expression workflows, from cloning, purification, to characterization.
- Design and execute protein expression and purification experiments in a variety of expression systems, from bacteria to mammalian cells
- Validate expressed proteins using SDS-PAGE, and western blot
- Performing in vitro and cell-based potency and ELISA assays
- Independently conduct experiments; maintain detailed records of experiments and outcomes; and work in collaboration with team members within and across departments
- Contribute to understanding protein structure and function that drives drug discovery efforts.
- Present findings to the immediate team and broader company
- Opportunities for new technology development with a strong team of scientists
|
| Skills: |
Qualifications:
- 2+ years of experience directly working with relevant molecular biology and protein methods, including cloning methods, primer/vector design, plasmid isolation and sequencing, protein expression and purification in a variety of expression systems, from bacteria to mammalian cells
- Experience using an ELN
- Interest in laboratory automation, data analysis, and data visualization
- Experience with biochemical analytical methods and assay development
- Good understanding of protein biochemistry, enzymology, and protein purification processes
- Ability to work effectively and collaboratively on cross-functional projects teams
- Excellent oral, presentation, and written communication skills
|
