· An exceptional team member that fosters a highly collaborative work environment. · A confident individual who speaks up, is open to input, and remains focused on achieving. the best results to achieve company goals. · A diligent scientist/engineer who enjoys process execution and scale up. · The ability to clearly present data, trend longitudinal data, draw conclusions, and communicate salient points concisely. · A strong sense of ownership and accountability; commitment to company’s mission.
Essential Functions:
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- Operate and maintain the Downstream pilot plant production line in company’s San Carlos facility.
- Preparation of buffers, execution of chromatography, tangential flow filtration, and normal flow filtration systems.
- Support for Upstream pilot plant operations.
- Develop and optimize process records that clearly instruct and efficiently facilitate capture of data.
- Schedule and manage logistics of routine pilot production of proteins to support company’s pipeline.
- Support scale up activities for processes as part of technology transfer to CMOs.
- Contribute to process development for protein processes as time allows.
- Run in-process tests and product quality assays to support pilot production.
- Generate written summaries of production runs.
- Packing columns from loose resin.
- Buffer preparation up to 200L.
Requirements:
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- BS in Chemical Engineering, Biochemistry, or a related discipline, with 2+years of industry experience.
- Strong protein purification knowledge and experience, including familiarity with AKTA Pilot (or Avant) chromatography systems and UNICORN software.
- Proficiency running analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
- Experience operating tangential flow filtration systems; single-pass TFF is a plus.
- Experience with Benchling ELN is a plus.
- Strong interpersonal skills, with excellent written and verbal communication skills.
- All employees require vaccination against COVID-19.