Summary:
Out client is looking for a highly skilled, motivated, and creative analytical scientist to join their Vaccine Product Development organization as Scientist I within Protein Development and Clinical Manufacturing. The Analytical Scientist I will assume a critical role of development and executing the key analytical methods to support the measurement of titer, impurities and product quality for in process intermediates. The successful candidate will support the set-up of analytical capabilities within protein process development group, development/optimization and qualification of in process analytical methods and apply the methods for process characterization. This position is for a scientific role which will be mostly lab based, this role will require excellent scientific judgment, independence, rigor and thorough record keeping.
Essential Functions:
- Set up instrument capabilities to enable the analytical methods development and qualification for process characterization.
- Develop/optimize analytical methods for biologic products using HPLC (size exclusion, ion exchange, reversed phase, etc), CE-SDS, PicoGreen, Capillary Western(Jess), A280, mass spectrometry, etc.
- Acquire and interpret data for protein titer, molecule characterization and process development studies.
- Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports.
- Assist in troubleshooting of instrumentation and test methods.
- Able to work well independently and in a team setting on assigned tasks, such as method development and sample testing.
- Participate in group meetings, present results of work, interpret data, and report results in an accurate manner.
- Work with lab automation to create high throughput methods leveraging liquid handling and robotic technologies.
- Work in collaboration with other scientists/SME to design experiments and advance more powerful analytical techniques.
Requirements:
- PhD with 0-2 year's experience, or B.S in Chemistry, Analytical Chemistry, Biochemistry, or related field with 8+ years relevant industry experience; MS with 5 years + industry experience in Pharma / Biotech industry required.
- Strong technical background in analytical chemistry. Hands on proficiency and with HPLC, CE-SDS, Spectroscopy, etc.
- Perform accurate and reliable data analysis and interpretation of experimental results related to process characterization.
- Ability to think critically and demonstrate troubleshooting and problem-solving skills.
- Maintain accurate records of experimental procedures, results and conclusion in compliance with regulatory guidelines.
- Team player, proactive and willing to work in a collaborative team environment.
- Scientific creativity and curiosity for applying new technologies to complex analytical challenges.
- All employees require vaccination against COVID-19.
Reports to: Staff Scientist, Protein Process Development
Location: San Carlos, CA
This job will be reviewed periodically and is subject to change by management.
NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.
The Company complies with all laws respecting equal employment opportunity and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law, including disability/veteran status. This position may require you to work onsite or interact in person with customers of the Company and/or work onsite from time to time at the Company’s facilities.